????????? ???????? ?? ?? ??? ?? ????????? ??? ??????????????? ????????????? ????? ???????? ??? ???? ?? ???????? ???? ?????.Tadalafil is fourteen-fold extra strong for PDE5 than for PDE11A1 and 40-fold more powerful for PDE5 than for PDE11A4, two with the four identified kinds of PDE11. PDE11 is undoubtedly an enzyme found in human prostate, testes,